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Lawrence L Rudel Selected Research

Sterol O-Acyltransferase

6/2012Cholesteryl esters associated with acyl-CoA:cholesterol acyltransferase predict coronary artery disease in patients with symptoms of acute coronary syndrome.
5/2011Pyripyropene A, an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia.
10/2009Estrogen decreases atherosclerosis in part by reducing hepatic acyl-CoA:cholesterol acyltransferase 2 (ACAT2) in monkeys.
4/2008Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss.
4/2008Identification of the interaction site within acyl-CoA:cholesterol acyltransferase 2 for the isoform-specific inhibitor pyripyropene A.
8/2006Liver-specific inhibition of acyl-coenzyme a:cholesterol acyltransferase 2 with antisense oligonucleotides limits atherosclerosis development in apolipoprotein B100-only low-density lipoprotein receptor-/- mice.
2/2003Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice.
8/2002Primates highly responsive to dietary cholesterol up-regulate hepatic ACAT2, and less responsive primates do not.

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Lawrence L Rudel Research Topics

Disease

37Atherosclerosis
07/2017 - 11/2002
9Cardiovascular Diseases (Cardiovascular Disease)
07/2017 - 08/2006
9Hypercholesterolemia
11/2015 - 08/2002
7Obesity
10/2019 - 07/2007
7Hepatocellular Carcinoma (Hepatoma)
09/2014 - 09/2005
5Inflammation (Inflammations)
11/2015 - 02/2008
4Body Weight (Weight, Body)
11/2015 - 05/2005
4Coronary Disease (Coronary Heart Disease)
05/2012 - 02/2003
4Insulin Resistance
06/2010 - 07/2007
4Metabolic Syndrome (Dysmetabolic Syndrome X)
06/2010 - 09/2008
4Gallstones (Gallstone)
11/2009 - 02/2003
3Atherosclerotic Plaque (Atheroma)
09/2015 - 02/2002
3Hyperlipidemias (Hyperlipidemia)
06/2012 - 09/2008
3Hypersensitivity (Allergy)
10/2009 - 02/2008
2Non-alcoholic Fatty Liver Disease
10/2019 - 05/2010
2Type 2 Diabetes Mellitus (MODY)
01/2017 - 01/2013
2Hypertriglyceridemia
11/2014 - 04/2010
2Abdominal Obesity
09/2012 - 07/2007
1Fibrosis (Cirrhosis)
10/2019
1Alcoholic Fatty Liver
10/2019
1Liver Cirrhosis (Hepatic Cirrhosis)
10/2019
1Hepatitis
10/2019
1Wilms Tumor (Wilm's Tumor)
02/2015
1Sitosterolemia
04/2013
1Acute Coronary Syndrome
06/2012
1Coronary Artery Disease (Coronary Atherosclerosis)
06/2012
1Breast Neoplasms (Breast Cancer)
01/2011
1Dyslipidemias (Dyslipidemia)
08/2010
1Thinness
06/2010
1Tangier Disease
04/2010

Drug/Important Bio-Agent (IBA)

30CholesterolIBA
11/2015 - 08/2002
14Lipoproteins (Lipoprotein)IBA
11/2014 - 02/2003
13oxidized low density lipoproteinIBA
02/2015 - 02/2002
9LipidsIBA
10/2019 - 11/2004
9Cholesterol Esters (Cholesteryl Esters)IBA
10/2014 - 08/2002
8Sterol O-AcyltransferaseIBA
06/2012 - 08/2002
7Fatty Acids (Saturated Fatty Acids)IBA
05/2012 - 12/2004
6Antisense OligonucleotidesIBA
01/2017 - 08/2006
6ApolipoproteinsIBA
01/2013 - 02/2002
5LDL CholesterolIBA
07/2017 - 05/2007
5EnzymesIBA
01/2017 - 08/2002
5cholesteryl oleateIBA
02/2015 - 05/2007
4Dietary Fats (Dietary Fat)IBA
07/2017 - 02/2003
4Messenger RNA (mRNA)IBA
11/2015 - 02/2008
4Proteins (Proteins, Gene)FDA Link
11/2015 - 06/2008
4Monounsaturated Fatty AcidsIBA
09/2015 - 02/2003
4Apolipoprotein B-100 (Apo B 100)IBA
09/2015 - 05/2007
4LDL Receptors (LDL Receptor)IBA
10/2014 - 12/2004
4Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA
01/2011 - 12/2004
4Apolipoproteins B (ApoB)IBA
04/2010 - 02/2003
4Triglycerides (Triacylglycerol)IBA
10/2007 - 02/2003
3AcyltransferasesIBA
10/2019 - 08/2006
3Sterol O-Acyltransferase 2IBA
11/2015 - 08/2006
3Oleic Acid (Oleate)IBA
02/2015 - 02/2004
3Proteoglycans (Proteoglycan)IBA
02/2015 - 01/2011
3Dietary CholesterolIBA
06/2012 - 08/2002
3Acyl Coenzyme A (Acyl CoA)IBA
05/2011 - 08/2006
3Fish OilsIBA
07/2010 - 12/2004
3Phospholipids (Phosphatides)FDA LinkGeneric
07/2010 - 12/2004
3Glucose (Dextrose)FDA LinkGeneric
06/2010 - 07/2007
3Omega-6 Fatty Acids (Omega 6 Fatty Acids)IBA
02/2009 - 02/2008
2trimethyloxamine (trimethylamine N-oxide)IBA
01/2017 - 01/2017
2dimethylaniline monooxygenase (N-oxide forming) (flavin-containing monooxygenase)IBA
01/2017 - 01/2017
21,11- O- o- methylbenzylidene- 7- O- p- cyanobenzoyl- 1,7,11- trideacetylpyripyropene AIBA
11/2015 - 11/2015
2pyripyropene AIBA
11/2015 - 05/2011
2LDL Lipoproteins (beta Lipoproteins)IBA
09/2014 - 12/2004
2HDL CholesterolIBA
09/2012 - 05/2005
2Syndecan-1 (Syndecan 1)IBA
01/2011 - 06/2008
2stearoyl-coenzyme A (stearoyl-CoA)IBA
06/2010 - 09/2008
2Trans Fatty AcidsIBA
06/2010 - 07/2007
2Stearoyl-CoA DesaturaseIBA
01/2010 - 10/2009
2Estrogens (Estrogen)FDA Link
10/2009 - 07/2007
2Toll-Like Receptor 4IBA
10/2009 - 09/2008
2Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA
04/2009 - 02/2003
2FatsIBA
11/2007 - 11/2002
2HydrolasesIBA
10/2007 - 10/2003
2Apolipoproteins E (ApoE)IBA
12/2003 - 02/2003
1Unsaturated FatsIBA
07/2017
1Biological ProductsIBA
07/2017
1Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
02/2016
1Alanine Transaminase (SGPT)IBA
11/2015
1poststatinIBA
11/2015
1Apolipoprotein L1IBA
02/2015
1Cytosolic acetoacetyl-CoA thiolase deficiencyIBA
11/2014
1BiglycanIBA
09/2013
1Phytosterols (Plant Sterols)IBA
04/2013
1ATP-Binding Cassette Transporters (ABC Transporters)IBA
04/2013
1Acetyl-CoA CarboxylaseIBA
01/2013
1hydroxide ionIBA
09/2012
1Calcifediol (Calcidiol)FDA Link
09/2012
1CytokinesIBA
08/2010
1alpha-Linolenic Acid (Linolenic Acid)IBA
07/2010
1Eicosapentaenoic AcidIBA
07/2010
1Anti-Inflammatory Agents (Anti-Inflammatories)IBA
06/2010
1Insulin (Novolin)FDA Link
06/2010
1Pharmaceutical PreparationsIBA
06/2010
1HDL LipoproteinsIBA
04/2010

Therapy/Procedure

3Therapeutics
06/2010 - 02/2003
1Nephrectomy
02/2015
1Glycemic Control
06/2010